beta-hydroxy-2-hydroxymethylene-17 alpha-methyl-5 alpha-androstan-3-one]
Formula: C 21 H 32 O 3
up to 8 weeks
Anabolic Ratio: 45:320
has been the strongest, oral steroidal compound, which is a derivative of
dihydrotestosterone, which has been currently only available for institutional
use in Mexico. Clinically, Anapolon had been often prescribed in efforts to
treat anemias that had been caused by deficient red cell production. The
androgenic and high anabolic properties of Anapolon have been substandard of Testosterone,
which had been perinined this compound to have also been a dramatic muscle
building product. Many athletes had claimed the strength and weight increases
had been very substantial within is a relatively short period of time. This
characteristic had allowed the compound of Anapolon to be a very popular choice
of oral steroidal compounds amongst many athletes, primarily those of the male
gender. Most athletes had frequently experienced a general weight increase of
approximately 10 to 15 lbs or more, within two weeks with the administration of
this compound. This of course, had been largely attributed to the tremendous
amount of water retention which had immediately increased the muscle diameters,
which in turn, had permitted a rapid increased size appearance. Consequently,
this retained amount of water in the muscle cells and joints had also
additionally provided a smooth appearance, as the size increase had been
quantitative, not qualitative. An advantageous effect of the water retention
however, had been the ability to eliminate, or having soothed associated joint
problems, which had been due to this side effect's subsequent lubricating
quality. This had often been appreciated by most athletes, as this
characteristic had frequently allowed for intense workouts, which had often
been previously somewhat restricted, due to associated aggravated pain in the
The Anapolon oral steroidal compound had further increased the number of red
blood cells, which in turn, had enabled the muscles to absorb more oxygen. This
had generally resulted in the muscle being able to have endured more physical
stress, which had been due to the significant increase in blood volume. A
"pump" effect had often been experienced when training particular
muscles, and had even become somewhat painful to the extent, that the performed
exercise had frequently been required to have been abandoned, in order to have
alleviated this sensation.
However, this perception of increased strength and power had commonly been
desired by all athletes who had practiced the self administration of this
compound, as this sensation had usually been indicative that the compound of
Anapolon had indeed, been performing to it's full capacity. Several athletes
had also claimed that another distinguishing trait of Anapolon, had been the
increased training duration's, as this compound had been able to have
stimulated the regeneration of the body, which often had enabled further muscle
building progress, and had stalled the possibility of over training.
However, although the substance of Anapolon had been powerful, it
unfortunately, also had imposed the highest threat for serious adverse
reactions out of any oral or injectable steroids compounds. A few athletes had
experienced excessive water retention which had sometimes resulted in high
blood pressure. Anapolon had very high DHT levels, and had been very toxic to
the liver, due to the characteristics of being C-17 alphaallrylated steroid.
Although the Anapolon steroidal compound had been known for quick strength and
mass gains, it's utilization had not been suitable for novices, and had only
been used by some athletes after a certain development had been achieved; or
consequently, the prior use of weaker steroid compounds had been experienced.
Anadrol 50(commonly called by athletes "A50"
or "A-bombs") was initially developed as a compound to help people
with anemia, and has since been used very successfully to aid people who are
suffering from many other diseases where weight loss is a concern. Thus, it is
clearly an effective agent for promoting weight gain, increasing appetite,
gaining strength, and increasing Red Blood Cell count. And, as with most
Anabolic/Androgenic Steroids (AAS), it has its downsides as well. Anadrol will
inhibit your bodys natural production of hormones (testosterone,
etc& ), will negatively affect your blood lipid profile, can cause water
retention, is notorious for causing headaches, and is also highly liver toxic
(in fact, it has the worst reputation for hepatoxicity out of all steroids).
Paradoxically, although one the benefits touted by its original manufacturer
(Syntex) is that it can be used to stimulate weight gain through increasing
appetite, taking too much may actually inhibit your appetite!
Anadrol Effects on Body
I think, in order to gain a complete understanding of
the Anadrol effects on body, we need to take a look at its advantages
contrasted with its disadvantages. Anadrol is a DHT-derived compound, and is
17-Alpha-Alkylated steroid, meaning that it has been altered at the 17th carbon
position to survive oral ingestion. Most oral steroids are 17aa, and this helps
them make it through your liver in a useful form. Sounds great, right? Lets
17alpha-alkylate everything! Well& as you can imagine, theres a down side.
Anadrol Side Effects
This 17aa alteration, which makes it possible for
Anadrol to survive its first pass through your liver, also makes it very taxing
on your liver. How taxing is A50 and how much weight can you gain from its use?
Well, there was a 30 week study done on A50 and, as you can expect, a
reasonable amount of side effects were noted. The fact that A50 causes some
side effects has really never been in debate. But how effective was the drug?
Well, first it should be mentioned that this study was done on people with AIDS
related wasting, and they actually gained weight (8+kg) while the control group
lost weight, and had increased mortality rates. (1). I suppose, if youre in a
study because you have a wasting disease which is also a terminal illness, you
dont want to end up in the control group& .Anyway, weight gain in this
study peaked at 19-20 weeks, though, so the last 10 weeks werent very
productive in this respect. Clearly, you wouldnt want to run Anadrol for 20
weeks, given its toxicity, but after that, any effect in terms of weight and
strength gains would be negligible. So, with regards to sides from Anadrol, and
the sheer fact that this study lasted so long (30 weeks), it should be apparent
that they can be kept under control and the drug can be used safely. People are
commonly told to limit their intake of A50 to 4 weeks or less& Im a bit
less conservative and think you can easily run A50 for 6 weeks or more.
From personal experience, however, I can tell you that
gains from Anadrol are quite dramatic for the first 3 weeks, and then quickly
level off. Unfortunately, I find that the side effects experienced from Anadrol
(which include a headache, bloating, elevated blood pressure, and a general
"unwell" feeling for me) remain for the entire duration of use&
.but I find, as usual, side effects for this drug are pretty much half legend
and half truth. Since Anadrol is derived from DHT, it cant actually convert to
estrogen (via the aromatase enzyme), and its not a progestin or a compound with
progestenic activity& so the estrogenic (?) side effects produced by it are
of a very mysterious nature. It has been speculated that perhaps it can
stimulate the estrogen receptor without actually being converted to
estrogen& thats about as plausible an explanation as Ive heard& However,
things really get strange, when Oxymetholone has been used in studies to alter the
female reproductive/menstrual cycle; in those cases, it has lowered plasma
progesterone levels! (7)One would expect that an AI (aromatase inhibitor)
wouldnt be of much use with this drug, but many have found that Letrozole
(which has, in some cases been shown to reduce estrogen in the body to an
undetectable amount)(6) can greatly reduce or even eliminate many of the more
noticeable side effects of Anadrol, such as the bloating.
As Ive stated, however, the sides from this drug are
certainly no joke, but are easily preventable, and controllable. One study even
showed very few sides for subjects using up to 100mgs of Oxymetholone (2). In
the original UnderGround Steroid HandBook, Dan Duchaine states that he used it
at doses up to 150mgs/day. Clearly, Anadrols hepatoxicity has been a bit
exaggerated, in some circles. Be that as it may, my suggestion is still to
limit Anadrols use to 6 weeks, at a maximum& even if just to err on the
side of caution. Of course, I have personally run this drug for much longer..
How should we use Anadrol? Id probably be willing to
include Anadrol in a cycle including injectable st
UnhideWhenUsed=eroids, but not other 17aa
compounds. Id make any 6-week-run of this compound begin at the start of a
cycle, as a form of "jumpstart" towards seeing gains quickly. The quick
gains you will get from Anadrol (up to a pound per day for the first 2 weeks
are not uncommon in Steroid.com members) are also just as quick to disappear
upon cessation of use& .unless you are simply using it as a kickstarter,
while waiting for your other compounds to kick-in. Ill go out on a limb here
and say that utilizing Anadrol as a "Jumpstart" is the most popular
use of this drug for athletes and bodybuilders today. Ill also say that this
drug is immensely popular with strength athletes who dont have to worry about
weight classes (Field athletes and strongmen), and with powerlifters in the
heavier weight brackets. Its also important to note that in one study by
Schroder et. Al (2) anadrol showed that it has the ability to lower serum SHBG
(Sex Hormone Binding Globulin& which binds to your free test and makes it no
longer useful for anabolism, among other things) concentrations by 54.9 25.8
and 45 16.2 nmol/l in the 50- and 100-mg treatment groups. This means there
will be more free test circulating around your body when you take this
drug& clearly, this would produce some synergy when stacked with other
steroids. Given the large amounts of weight and strength which can be gained in
a relatively short time span on this drug, Im sure this comes as no surprise to
Another important and often understated characteristic
of this compound is that Oxymetholone doesnt bind well to the androgen receptor
(Relative Binding Affinity = too low to be determined) (3) which is the lowest
Ive ever read about. Basically, what this tells me is that there are a lot of
non-receptor mediated effects from this steroid, making it a very potent
addition to ANY BULKING stack, because it wont be competing for the receptor sites
with the other steroids youre using. Its also, as you may have guessed a very
poor choice for a cutting stack.
What is an Anadrol Cycle? How much should you use?
Well, this is actually one of the most interesting facts about Anadrol. You see,
most steroids produce what we call a "dose respondent curve" which is
a fancy way of saying "the more you use, the more you gain."
Anadrol is one of the few steroids where the dose
respondent curve flattens out very quickly. When you take 50mgs of Anadrol,
youll make some very good gains. When you take 100mgs of Anadrol, youll make
even more gains. However, it has been found that 100mgs/day is as effective for
weight gain as 150mgs/day but produces less side effects and was less toxic
(4). I feel that the jump from 50mgs to 100mgs constitutes an acceptable rise
in benefit vs. cost, but this is not the case as dosages get over 100mgs. Now,
lets see how 50mgs and 100mgs of Oxymetholone actually effect strength, when
compared with each other:
Relative (%) changes in strength are shown for the
groups receiving placebo (filled bars), 50 mg/day oxymetholone (open bars), and
100 mg/day oxymetholone (gray bars). Nos. above bars represent relative change
(%) from baseline to week 12 for the 1-repetition maximum tests of strength.
Error bars represent 1 SE from the mean. * Significant difference from placebo,
P < 0.05; significant difference from placebo by Wilcoxon test, P < 0.02.
See text for additional statistical analyses.
As you can see, in this study, doubling the dose of
Anadrol nearly doubled the strength gains of the test subjects. Now, when we
look at changes in body composition from Oxymetholone (chart below) we can see
that although the guys taking the 100mgs (vs. the 50mgs group) had more fat
lost and more Lean Body Mass gained, it wasnt as dramatic as the differences in
strength gains between the two groups:
Changes in body composition are shown for the groups
receiving placebo (filled bars), 50 mg of oxymetholone per day (open bars), and
100 mg per day (gray bars). Numbers above the bars represent the mean absolute
changes and the error bars are 1 SE. For total lean body mass (LBM) and total
fat, differences among the 3 groups were significant (P < 0.0001, one-way
ANOVA). * Significant differences from placebo, P 0.001.
Although I am usually not inclined to posit
speculations on why a particular drug does or doesnt do something, in this case
I will. Im guessing that the higher doses of Anadrol cause enough appetite
suppression (at least anecdotally) to make eating rather difficult. It can also
resistance and glucose intolerance (5). This has the effect of making
macronutrient absorption more inefficient, and could also be a factor in
reducing gains when the dosage goes over 100mgs/day. Unfortunately, Anadrol
also has a reasonably profound effect on your bodys natural hormonal system, on
par with most other oral steroids, but not as bad as most injectables, and its
certainly not as harsh on your lipid profile as many anabolics are
Anadrol Body Building
(2). As an interesting side note, some of the medical
literature on this compound suggests a dose of 1-5mgs per kg of bodyweight. Ill
pause a second here for you to figure out how absurdly high of a dose that
would translate to for the average bodybuilder!
To Buy Anadrol Liquiad Anadrol and others
This steroid is very available on the black market in
the form of capsules, tablets (some are even 75mgs!), liquid, and even paper. Prices
will vary, and be indicative of many different factors including the form you
buy this compound in (paper will usually be the most expensive, and liquid the
least), and where you live. In any case, you shouldnt be paying more than
$2.50-3.00 per 50mgs.
Charts from reference 2:
Am J Physiol Endocrinol Metab 284: E120-E128, 2003. First
published September 24, 2002; doi:10.1152/ajpendo.00363.2002 0193-1849/03
- Br J
Nutr. 1996 Jan;75(1):129-38.
et al. Am J Physiol Endocrinol Metab 284:E 120-28
Clin Trials. 2003 May-Jun;4(3):150-63.
- J Clin
Endocrinol Metab. 1981 Nov;53(5):905-8
Behav. 2004 Apr;5(2):260-3
- Am J
Obstet Gynecol. 1973 Sep 1;117(1):121-5.
Anadrol cycles are some of the most common cycles in performance
enhancing but as with any anabolic steroid or supplement of any form you
need to know how to take it if youre going to truly reap a reward. By and large
the strong majority of Anadrol cycles will be for the purpose of bulking during
off-season periods of use, as this is the steroids primary
purpose; to increase size and strength. However, there are those who will
include Anadrol cycles into their cutting phase and almost always this is among
competitive bodybuilders as they are generally the only ones who
will find this useful. Some hardcore gym rats who are not competitors of any
kind may do this as well but the effect is so short lived its generally not a
worthwhile practice for them.
Bulking Anadrol Cycles:
For the strong majority Anadrol cycles will be
during the off-season and for the strong majority the period of use will be at
the front end of the total cycle as part of a kick start to a total stack. As this
steroid is very
fast acting it will bring results to the cycle very quickly and as it provides
synergy among the other anabolic steroids present it gives them a greater
ability early on in order to get the ball rolling.
For most all 50mg per day Anadrol cycles is the
starting point and often all the Anadrol anyone will ever need; however, some
more experienced individuals may opt for doses of as much as 100mg per day but
you are urged to find out how you respond to a lower dose first before ever
experimenting with 100mg. Make no mistake, in either case massive gains can
come; if enough food is being taken in 50mg of this steroid per day can easily
yield a 20lb gain in a month, perhaps even more.
How long should Anadrol cycles last? Generally
speaking 4-6 weeks and thats it. Those who extend use past the 6 week mark will
more than likely find it to be a waste of a good steroid as this steroids
effectiveness is only short lived and breaks must be taken. Once the 4-6 week
mark has passed it is time to rely on the other anabolic
steroids present to do the work. You will also find this falloff effect to be
greatly revolving around dose as well; individuals who break the 100mg per day
mark will not find gains to be much more significant and it has been shown that
such doses can seriously kill ones appetite making bulking very difficult.
For those who are implementing Anadrol cycles you
will find it stacks
well with most any other anabolic androgenic steroid; most notably testosterone.
Common stacks often include testosterone of any form, as well as either Nandrolone
of any form. There really isnt a steroid out there that is a poor option to
stack with Anadrol.
Cutting Anadrol Cycles:
Even though primarily a bulking steroid Anadrol
cycles can be useful to the dieting competitive bodybuilder.
Unlike our bulking use this period of use will take place at the end of the
cycle, shortly before the competition is to take place. How it works is simple;
the presence of this steroid allows the individual to fill out to a greater
degree giving the muscles just that, a rounder and fuller look once on stage.
It is very important to note, the individual should have some experience with
Anadrol cycles before ever trying this as to know with certainty how they
respond to the steroid. Anadrol can cause a fair amount of water retention and
for a competitor that is the last thing you want. However, if you understand
how to control the steroid, if you are in shape and are supplementing with a
good aromatase inhibitor you will enjoy this benefit.
For most 50mg per day for 4 weeks will suffice.
This should be for the 4 weeks leading up to the show and it cannot be stressed
enough, you need to be in shape. If you are behind in your diet
this is a method you are going to need to forgo as the results can be horrible
and effectively ruin your chances at placing well.