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Selank 5 mg
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Selank 5 mg

Item 12759


Systematic (IUPAC) name

1-[2-({1-[2-({1-[6-Amino-2-(2-amino-3-hydroxy-butyrylamino)-hexanoyl]-pyrrolidine-2-carbonyl}-amino)-5-guanidino-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-acetyl]-pyrrolidine-2-carboxylic acid

Clinical data

Pregnancy cat.  ?

Legal status  Prescription only

Routes Nasal muscosa

Identifiers

ATC code  ?

ChemSpider 9940290 

Synonyms Selanc; L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-Proline

Chemical data

Formula C33H57N11O9 

Mol. mass 751.9

InChI[show]

 

Selank (Russian: Cеланк) is a nootropic, anxiolytic peptide based drug developed by the Institute of Molecular Genetics of the Russian academy of sciences. Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It is a synthetic analogue of a human tetrapeptide tuftsin.

Pharmacology

Selank is a synthetic analogue of the immunomodulatory peptide tuftsin; as such, it mimics many of its effects. It has been shown to modulate the expression of Interleukin-6 (IL-6) and affect the balance of T helper cell cytokines.[1] It is has been shown to influence the concentration of monoamine neurotransmitters[2] and induce metabolism of serotonin.[3] There is evidence that it may also modulate the expression of Brain-derived neurotropic factor (BDNF) in rats.[4]

Clinical trials

In clinical trials, the drug has shown to provide a sustained nootropic and anxioytic effect, which is useful for the treatment of generalized anxiety disorder (GAD).[1] Selank has an advantage over traditional anxiety treatments, such as benzodiazepines, as it has no sedating or cognitive side effects and no associated addiction or withdrawal syndrome. Selank also has very low toxicity with an overdose proving harmless even up to 500 times the effective dose. When released, the drug will be used as a 0.15% aqueous solution which is applied to the nasal mucosa in drops. It is thought that this is the best method for absorbing peptide based drugs. The drug can be used to suppress feelings of fear and anxiety in people with anxiety disorders and to stimulate learning and memory in healthy people.[citation needed]

As of 2010, the drug has completed stage III clinical trials in Russia and is currently waiting to be authorized for general use in that region.[citation needed] It is unknown if the drug will be marketed in the West or other world regions at this stage.

Selank is closely related to another nootropic drug, Semax, also developed by the Institute of Molecular Genetics in Russia. This drug is currently available in Russian and Ukrainian pharmacies.[5]

References

1.      ^ a b Uchakina, ON; Uchakin, PN; Miasoedov, NF; Andreeva, LA; Shcherbenko, VE; Mezentseva, MV; Gabaeva, MV; Sokolov, OIu et al. (2008). "Immunomodulatory effects of selank in patients with anxiety-asthenic disorders". Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoi promyshlennosti Rossiiskoi Federatsii, Vserossiiskoe obshchestvo nevrologov [i] Vserossiiskoe obshchestvo psikhiatrov 108 (5): 71–5. PMID 18577961. edit

2.      ^ Narkevich, VB; Kudrin, VS; Klodt, PM; Pokrovskiĭ, AA; Kozlovskaia, MM; Maĭskiĭ, AI; Raevskiĭ, KS (2008). "Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study". Eksperimental'naia i klinicheskaia farmakologiia 71 (5): 8–12. PMID 19093364. edit

3.      ^ Semenova, TP; Kozlovskiĭ, II; Zakharova, NM; Kozlovskaia, MM (2010). "Experimental optimization of learning and memory processes by selank". Eksperimental'naia i klinicheskaia farmakologiia 73 (8): 2–5. PMID 20919548. edit

4.      ^ Inozemtseva, LS; Karpenko, EA; Dolotov, OV; Levitskaya, NG; Kamensky, AA; Andreeva, LA; Grivennikov, IA (2008). "Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo". Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / translated from Russian 421: 241–3. PMID 18841804. edit

5.      ^ Institute of Molecular Gentics: Translation of

 



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